The Organoid Centre

  • Hadassah at the Forefront of Research

Hadassah UK’s policy of investing in areas to stimulate Research & Development brings specialist researchers and diverse experts together to look at new ways of treating people with complex illnesses. This started with the creation of the Wohl Institute for Translational Medicine and continues with the creation of the Hadassah Technological Incubator Hub, due to open next year. 

 

Within the Wohl Institute is Hadassah’s revolutionary new Organoid Centre, a first of its kind in Israel. Organoids are considered one of the most significant scientific advances of the last decade in medical research, allowing scientists to study diseases, understand their mechanisms, and to develop and test potential new treatments.

What are Organoids?

 

Organoids are lab-grown tissues that mimic the features and functions of a tissue in the body. To produce organoids, biopsies are taken from different tissues in a patient’s body, healthy or diseased, and grown in a special gel that allows the cells to replicate and self-organise into three-dimensional structures in the lab.

 

Organoids in Hadassah’s bio-bank are stored with the medical history of the individual patient. Doctors can use the samples to experiment with various treatments for the patient’s specific condition and investigate the effect of different medicines to identify the most effective combination for them.

Multiple samples can be created from organoids and frozen for long-term storage; once thawed the samples can be used as an unlimited resource for important research.

 

The potential applications of organoids are vast and varied:

  • Medicines can be screened for effectiveness and safety, reducing the need for animal testing and accelerating the discovery of new treatments.
  • The effects of environmental factors on tissues can be studied to develop personalised treatments for patients based on their individual genetic makeup.
  • Organoids can help us understand the mechanisms of aging and age-related diseases to develop strategies for healthy aging and to extend our lifespan.
  • Most significantly, organoids can help researchers study rare genetic and infectious diseases as well as the biology of cancer in the body.

The Wohl Institute for Translational Medicine geared toward applied research for personalised medicine, was created at Hadassah  in 2019. 

The multidisciplinary institute is a result of a partnership among the Wohl Legacy, Hadassah UK, and the Hadassah Medical Organisation.

 

The Wohl Institute offers state-of-the-art imaging technologies for pre-clinical research to researchers from Hadassah Hospital and other Israeli hospitals and universities and is the first of its kind in Israel.

 

The mission of Hadassah’s Wohl Institute for Translational Medicine is to serve as a national centre for innovative preclinical research, promoting studies designed to elucidate unsolved human diseases and the development of new therapies, for the benefit of all. Scientists, researchers, clinicians, and industry partners join together at the Institute to make research breakthroughs happen and to translate discoveries into innovative healthcare treatments.

 

Fifty research groups have partnered with the Institute on vital challenges in medical science ranging from oncology, orthopedics, cardiology, neurology, metabolic syndrome, diabetes, and kidney disease to aging. Research at the Institute has generated over 40 peer-reviewed scientific articles in leading journals, and a new generation of young scientists is being trained to leverage advanced preclinical imaging for scientific medical research.

 

The Wohl Institute includes an organoid center. Miniature 3D tissue culture replicas of our body organs, organoids are powering a revolution in biomedical research, transforming our ability to model the impact of disease and promising breakthroughs in personalised medicine.

New Round Tower

Through the rebuilding, renovation and expansion of our Round Tower at Hadassah Ein Kerem, we will significantly expand our capacity to serve the growing population of Jerusalem. This will create a more patient-centred healing environment and provide necessary resources to support the ground-breaking work of our doctors, researchers, nurses, and staff members. Massive refurbishment is needed to transform this outdated facility into a vibrant hub of future medicine.

Research

Applied Medicine

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